Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (1071)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (640)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-101436A

Sematilide hydrochloride	Inhibitor	99.85%
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective I_Kr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K⁺ current (IC₅₀=25 μM). Sematilide is a class III antiarrhythmic agent.

HY-106570

Tripamide	Inhibitor	98.78%
Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent.

HY-17451

Glibornuride	Inhibitor	98.92%
Glibornuride is a blocker of ATP-sensitive K⁺ channels (K_ATP channel) with a pK_i of 5.75. Antidiabetic agent.

HY-126028

(-)-Sotalol	Inhibitor	99.00%
(-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a K_d of 0.60 μM. (-)-Sotalol can be used for the research of cardiac arrhythmias.

HY-122560

VU0134992	Inhibitor	99.30%
VU0134992 is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC₅₀ of 0.97 µM. VU0134992 is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC₅₀=9 µM) at -120 mV.

HY-13710

Dimethindene	Inhibitor	98.94%
Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K⁺ currents.

HY-161092A

KIO-301 chloride hydrochloride	Inhibitor	99.61%
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels).

HY-P1409A

ADWX 1 TFA	Inhibitor	98.37%
ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases.

HY-120375

LUF7346	Inhibitor	99.81%
LUF7346 is a potent Kv11.1 (hERG) channel negative allosteric modulator, with an IC₅₀ of 35.6 ± 3.2 nM.

HY-12533A

Disopyramide phosphate	Inhibitor	99.85%
Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action.

HY-114633

VU625	Inhibitor	98.47%
VU625 is an inhibitor for potassium channel, that selectively inhibits mosquito Aedes aegypti inward rectifier potassium channel 1 (AeKir), with IC₅₀ of 96.8 nM in HEK293 cell. VU625 can be used in development of insecticide.

HY-P4742A

6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA	Inhibitor
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research.

HY-17504AS1

Rosuvastatin-d₆	Inhibitor
Rosuvastatin-d₆ (ZD 4522-d₆) is deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks hERG current with an IC₅₀ of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

HY-155516A

cis-KV1.3-IN-1	Inhibitor	99.19%
cis-KV1.3-IN-1 (Compound cis-18) is a cis-isomer of KV1.3-IN-1 (HY-155516). cis-KV1.3-IN-1 is an inhibitor of the KV1.3 channel. cis-KV1.3-IN-1 (10 μM) inhibits KV1.3 by 25.53% in Xenopus oocytes expressing human hKV1.3.

HY-B0753S

Gliclazide-d₄	Inhibitor	99.90%
Gliclazide-d₄ (S1702 D₄) is the deuterium labeled Gliclazide. Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC₅₀ of 184 nM. Gliclazide is used as an antidiabetic.

HY-132201

MK-8153	Inhibitor
MK-8153 is a potent, selective and orally active inhibitor of renal outer medullary potassium channel (ROMK), with IC₅₀s of 5 nM, 34 μM for ROMK electrophysiology (EP) and hERG EP, respectively. MK-8153 can be used as the diuretic/atriuretic.

HY-14188S

Amiodarone-d₄ hydrochloride	Inhibitor	99.58%
Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC₅₀ of ～45 nM. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias.

HY-N5006

Guanfu base G	Inhibitor	99.91%
Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC₅₀ of 17.9 μM.

HY-14848A

Naluzotan hydrochloride	Inhibitor	99.63%
Naluzotan hydrochloride is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC₅₀ and K_i of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K⁺ channel blocker, with IC₅₀ of 3800 nM.

HY-14187S

Amiodarone-d₁₀ hydrochloride	Inhibitor	98.81%
Amiodarone-d₁₀ (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

321compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (1071)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (1071):